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Results of the in vitro evaluations (activity and cytotoxicity on HepG2) of the 21 compounds presenting both good solubility in the culture medium (Schneider’s Drosophila Medium) and antileishmanial <t> EC 50 </t> activity values < 30 µM.
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Results of the in vitro evaluations (activity and cytotoxicity on HepG2) of the 21 compounds presenting both good solubility in the culture medium (Schneider’s Drosophila Medium) and antileishmanial EC 50 activity values < 30 µM.

Journal: Pharmaceuticals

Article Title: Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential

doi: 10.3390/ph17070878

Figure Lengend Snippet: Results of the in vitro evaluations (activity and cytotoxicity on HepG2) of the 21 compounds presenting both good solubility in the culture medium (Schneider’s Drosophila Medium) and antileishmanial EC 50 activity values < 30 µM.

Article Snippet: EC 50 values were calculated by non-linear regression analysis processed dose-response curves, using TableCurve 2D V5.0 software (Systat Software Inc. (Palo Alto, CA, USA)).

Techniques: In Vitro, Activity Assay, Solubility

Sensitivity of wild-type and NTR-overexpressing L. donovani promastigotes to compound 14c .

Journal: Pharmaceuticals

Article Title: Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential

doi: 10.3390/ph17070878

Figure Lengend Snippet: Sensitivity of wild-type and NTR-overexpressing L. donovani promastigotes to compound 14c .

Article Snippet: EC 50 values were calculated by non-linear regression analysis processed dose-response curves, using TableCurve 2D V5.0 software (Systat Software Inc. (Palo Alto, CA, USA)).

Techniques: